For best results, clean your Nike shoes immediately after exposing them to dirt.
Repeat these steps to attempt to remove persistent stains. Nike doesn't recommend any alternative cleaning methods, placing your shoes in a washing machine or dryer, or using any other products on your shoes such as bleach or other chemicals.
Saddle soap can soften leather and is recommended only on leather components of shoes that aren't subjected to excessive stress. Don't use saddle soap on soccer cleats, basketball shoes, golf shoes, training shoes or any other shoes designed for activities involving lateral movement.
If these steps don't reduce shoe odor, replace the insoles. Replacement insoles are available at most sporting goods and shoe stores.